Abcam, ab229503, Anti-STOP antibody

Size: 100µL
Rabbit Polyclonal STOP antibody. Suitable for IHC-Fr, WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAP6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAP6. The exact immunogen used to generate this antibody is proprietary information.Q96JE9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STOP also known as Oligophrenin-1 is a protein with a mass of approximately 88 kDa. It plays a mechanical role in the regulation of microtubule stability and dynamics. STOP is expressed in the nervous system particularly in neurons where it is involved in the cytoskeletal network. In addition to its presence in the brain STOP levels are also detectable in other tissues albeit at lower expressions compared to neuronal cells.
Biological function summary
In stabilizing microtubules STOP contributes to synaptic plasticity and proper neuronal function. As a part of the cytoskeleton regulation complex it enhances neuronal processes necessary for cognitive functions. This protein interacts with tubulin and other microtubule-associated proteins to support the structural integrity required for effective signal transmission in the nervous system.
Pathways
STOP's role in microtubule stability is integrated into neuronal growth and signaling pathways. It interacts with pathways that involve proteins such as MAP2 and Tau important for maintaining axonal transport and neuronal structure. These pathways ensure proper neuron function and are essential for brain development and neurotransmission processes.
STOP is related to neurological conditions such as schizophrenia and intellectual disabilities. Disruptions or mutations in the STOP protein can interfere with microtubule dynamics affecting neuronal stability. In disorders like schizophrenia STOP-related dysfunctions connect with abnormal interactions with proteins like CRMP2 furthering neural circuitry impairments and contributing to disease pathology.