Abcam, ab229802, Anti-SLC23A2 antibody

Size: 50µL
Rabbit Polyclonal SLC23A2 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC23A2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC23A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UGH3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC23A2 also known as SVCT2 is a sodium-dependent vitamin C transporter with a molecular mass of approximately 71 kDa. This protein functions by facilitating the active transport of vitamin C (ascorbic acid) across cellular membranes using the sodium gradient as a driving force. SLC23A2 is expressed in a variety of tissues prominently in the brain eyes and adrenal glands indicating its significant role in transporting vitamin C to vital organs that are sensitive to oxidative stress.
Biological function summary
SLC23A2 plays a pivotal role in maintaining vitamin C homeostasis within specific tissues. By actively transporting vitamin C into cells it ensures adequate antioxidant protection and collagen synthesis which are essential for tissue repair and immune function. As part of its biological role SLC23A2 does not associate with larger protein complexes but operates as an individual transporter to perform its function effectively.
Pathways
The activity of SLC23A2 is integrated into the ascorbate and aldarate metabolism pathway. It is closely related to the recycling of ascorbate impacting the body's ability to counteract oxidative stress. Additionally SLC23A2 works alongside other transport proteins such as SLC23A1 contributing to overall vitamin C homeostasis and impacting the function of the oxidative stress response pathway.
SLC23A2 has been implicated in conditions linked to vitamin C deficiency and oxidative damage. Disorders such as scurvy and neurodegenerative diseases have shown associations with altered SLC23A2 function. The transporter’s interactions with proteins involved in neuronal health and oxidative stress response suggest its potential involvement in these disorders. Understanding SLC23A2’s role in these conditions could provide therapeutic insights into managing related oxidative stress and tissue integrity issues.