Abcam, ab229832, Anti-ETV7 antibody

Size: 50µL
Rabbit Polyclonal ETV7 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETV7 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ETV7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q9Y603

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ETV7 also known as TEL2 is a member of the ETS family of transcription factors with a molecular weight of approximately 53 kDa. This protein localizes predominantly in the nucleus and influences gene expression regulation. ETV7 is expressed in a variety of tissues with notable expression levels in hematopoietic cells. Its role extends to modulating different genes critical for cellular proliferation and differentiation.
Biological function summary
ETV7 acts as a transcriptional repressor and influences immune responses and cell cycle regulation. This protein functions as part of larger transcriptional complexes interacting with other cofactors to modulate gene expression. ETV7 influences hematopoiesis impacting both the development and function of blood cells by repressing certain cytokine receptors and transcription factors tightly controlling the cellular environment.
Pathways
ETV7 plays an integral role in pathways related to hematopoiesis and immune cell regulation. It participates in the JAK-STAT signaling pathway collaborating with proteins such as STAT5 to regulate immune responses and cell proliferation. Additionally ETV7 is involved in the regulation of cytokine signaling pathways impacting cellular growth and immune system balance.
ETV7 holds significance in the development of certain cancers particularly hematological malignancies. It has associations with acute myeloid leukemia (AML) where its overexpression contributes to leukemogenesis alongside proteins like FLT3. ETV7 also plays a role in B-cell chronic lymphocytic leukemia (CLL) affecting the balance of pro-survival and apoptotic mechanisms further linking its activity with the tumor suppressor protein TP53. Understanding ETV7's interactions helps to illuminate its potential as a therapeutic target in these conditions.