Abcam, ab229979, Anti-EFCAB7 antibody

Size: 50µL
Rabbit Polyclonal EFCAB7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EFCAB7 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EFCAB7 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.A8K855

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EFCAB7 also known as EF-hand calcium-binding domain 7 is a protein that interacts primarily with molecular processes within cells. It possesses a mass of approximately 55 kDa. Researchers find EFCAB7 expressed mainly in human tissues with particular emphasis in the brain and testes. The protein shows involvement in calcium binding due to the presence of EF-hand motifs which plays a role in modulating its function.
Biological function summary
EFCAB7 contributes to essential cellular functions beyond just calcium binding. It acts as a part of protein complexes that regulate intracellular signaling pathways. Studies show that EFCAB7 plays a role in cilia formation and function which is important for cell motility and signaling. Its interaction with other proteins highlights its significance in cellular dynamics and homeostasis.
Pathways
Scientists have identified EFCAB7 as a critical participant in the primary cilium biogenesis pathway. This involvement links it with the Sonic Hedgehog signaling pathway an important pathway for embryonic development and cell differentiation. EFCAB7 also interacts with Nek1 a kinase known for its role in ciliogenesis indicating a cooperative functionality between these proteins within these pathways.
Alterations or dysregulation in EFCAB7 can impact conditions such as Joubert syndrome a ciliopathy affecting brain development. The protein's interaction with Nek1 also connects it to polycystic kidney disease where ciliary dysfunction is a primary factor. Researchers continue to examine these associations aiming to understand better the pathogenic mechanisms wherein EFCAB7 plays a role.