Abcam, ab232928, Anti-Salusin alpha antibody

Size: 100µg
Rabbit Polyclonal Salusin alpha antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Torsin-2A aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Torsin-2A aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8R1J9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab232928 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Salusin alpha also known as SAL-A is a bioactive peptide with a molecular weight of approximately 28 amino acids. It derives from the same precursor as salusin beta. Its primary activity involves interaction with various receptors influencing cardiovascular and metabolic processes. This peptide is expressed in multiple tissues including the adrenal glands kidney and central nervous system. In cells it can be secreted to exert effects in autocrine and paracrine signaling.
Biological function summary
Salusin alpha contributes significantly to the regulation of blood pressure and lipid metabolism. Although not part of a large protein complex it operates independently to impact these processes. Its presence in vascular tissues points to a role in vasodilation aiding in the modulation of vascular tone. It also influences cholesterol uptake and storage presenting potential implications for metabolic health.
Pathways
Salusin alpha plays a role in the renin-angiotensin system and in lipid metabolism. In the renin-angiotensin system it modulates blood pressure by affecting renal function and vascular resistance. Additionally in lipid metabolism its interactions with proteins such as leptin help regulate energy storage and expenditure. These pathways indicate its versatility in maintaining cardiovascular and metabolic stability.
Salusin alpha shows particular relevance to hypertension and atherosclerosis. Its regulatory effect on blood pressure links it closely to hypertension while its role in lipid metabolism ties it to atherosclerosis. These conditions involve proteins such as angiotensin and LDL receptors which influence the development and progression of cardiovascular diseases. Understanding salusin alpha's activity may offer insights into therapeutic opportunities for these common health challenges.