Abcam, ab232936, Anti-ZC3H14 antibody

Size: 100µL
Rabbit Polyclonal ZC3H14 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZC3H14 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZC3H14 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6PJT7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab232936 was affinity purified using an epitope specific to ZC3H14 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The zinc finger CCCH domain-containing protein ZC3H14 also known as N4BP3 or DFP1 functions as a RNA-binding protein and weighs approximately 95 kDa. This protein is expressed in several tissues with higher levels observed in the brain. It performs a critical role in post-transcriptional regulation by binding to polyadenylated RNA. ZC3H14 might directly influence mRNA stability and decay which are key components of gene expression regulation.
Biological function summary
Beyond its RNA-binding capacity ZC3H14 makes a significant impact on neuronal function as it associates with particular RNA processing activities. Though not formally part of a complex it has interactions that suggest it collaborates with other proteins in the cell to perform its functions. Its activity is particularly important in maintaining proper levels of gene expression in neurons which is critical for their health and function.
Pathways
The work of ZC3H14 in post-transcriptional regulation affects important processes such as mRNA surveillance and RNA turnover pathways. These pathways play important roles in ensuring that aberrant mRNA transcripts do not accumulate in cells. Within these pathways ZC3H14 might engage with other proteins like UPF1 which is an important factor in nonsense-mediated decay. This interaction ensures only properly processed mRNAs are translated into proteins therefore maintaining cellular homeostasis.
Abnormal function or expression of ZC3H14 links to neurological conditions notably intellectual disabilities. The mutation or loss of function of this protein leads to improper mRNA processing and neuronal dysfunction. ZC3H14 also connects to disorders of protein homeostasis due to its involvement with RNA-binding proteins that regulate gene expression in the nervous system. Understanding its precise role and interactions may provide insights into therapeutic strategies for diseases such as these.