Abcam, ab233256, APC Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]

Size: 100Test
Mouse Monoclonal Bone marrow stromal cell antigen 1 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human, Primates samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human BST1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SY11B5,
Isotype:IgG1,
Conjugation:APC,
Excitation/Emission:Ex: 650nm, Em: 660nm,
Carrier free:No,
Reacts with:Human, Primates,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human BST1. The exact immunogen used to generate this antibody is proprietary information.Q10588

Properties and Storage Information:
Form-Liquid, Purification technique-Size-exclusion chromatography, Storage buffer-pH: 7.4Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.
Biological function summary
BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.
Pathways
BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.
Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.