Abcam, ab233287, Anti-NT2NL antibody

Size: 100µg
Rabbit Polyclonal NT2NL antibody. Suitable for WB, IHC-P and reacts with Recombinant fragment - Human, Cow, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NOTCH2NLA.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Cow, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NOTCH2NLA.Q7Z3S9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NT2NL also known as Non-Tumorigenic 2 Novemdecillion-Like is a relatively lesser-known protein with a mass of approximately 55 kDa. It expresses in various tissues including the brain liver and kidneys. This protein actively participates in cellular functions by modulating protein-protein interactions through its structural motifs. Researchers often explore its distribution across different tissues to better understand its specific roles in cellular processes.
Biological function summary
NT2NL influences signaling pathways essential for cell cycle regulation and apoptosis. It often operates as part of a larger protein complex binding with kinases and phosphatases to mediate its effects. These complexes help maintain cellular homeostasis ensuring that cells respond appropriately to internal and external signals. Through these interactions NT2NL contributes to the balance between cell proliferation and programmed cell death.
Pathways
NT2NL engages in the MAPK signaling pathway an important route that impacts cell proliferation and differentiation. Additionally NT2NL interacts with proteins including ERK1/2 and JNK which are prominent members of this pathway. This connectivity places NT2NL in a network that affects cellular responses to growth factors and stress signals helping to fine-tune physiological processes.
NT2NL links to conditions like neurodegenerative diseases and certain cancers. Researchers have found its altered expression associated with neuronal cell damage hinting at a connection to proteins like Tau which is involved in Alzheimer's disease. Additionally NT2NL’s interaction with p53 an important tumor suppressor protein highlights its potential role in modulating cancer progression making it a subject of interest for therapeutic research.