Abcam, ab233445, Anti-LETMD1/HCCR-1 antibody

Size: 100µg
Rabbit Polyclonal LETMD1/HCCR-1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LETM1 domain-containing protein 1 aa 150-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Cow, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LETM1 domain-containing protein 1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q6P1Q0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LETMD1 also known as HCCR-1 functions mechanically as a mitochondrial protein that plays a role in regulating mitochondrial activity and cellular apoptosis. With a mass of approximately 60 kDa LETMD1/HCCR-1 is expressed in various tissues including the liver kidney and lung. This protein has been identified to participate in the mitochondrial pathways and contribute to cellular homeostasis and energy metabolism.
Biological function summary
LETMD1/HCCR-1 affects cellular processes like cell growth and death by impacting the mitochondrial function critical to these processes. Although not specifically a component of a known complex this protein influences important cellular dynamics. Its role in the regulation of apoptosis links LETMD1/HCCR-1 to cellular survival implying its importance in balancing cell proliferation and death under physiological conditions.
Pathways
LETMD1/HCCR-1 is associated closely with apoptosis and mitochondrial pathways. The protein regulates apoptosis interacting with members of the Bcl-2 family of proteins which are important in apoptosis regulation. LETMD1/HCCR-1's connection to mitochondrial dynamics also overlaps with pathways involving mitochondrial fusion and fission highlighting its integrative role in maintaining cellular energy balance and function.
LETMD1/HCCR-1 links to cancer and neurodegenerative disorders. Overexpression of LETMD1/HCCR-1 has been noted in various cancers where it may promote tumor cell survival through inhibition of apoptosis. Neurodegenerative diseases such as Alzheimer's disease also show LETMD1/HCCR-1 involvement possibly through its interaction with proteins like p53 which is significant in cell cycle regulation and apoptosis. Understanding LETMD1/HCCR-1's interaction with these proteins aids in exploring therapeutic targets for these conditions.