Abcam, ab233708, Anti-NR3B antibody [2A8E11]

Size: 100µg
Mouse Monoclonal NR3B antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GRIN3B aa 100-300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2A8E11,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRIN3B aa 100-300. The exact immunogen used to generate this antibody is proprietary information.O60391

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NR3B also known as Nerve Growth Factor-inducible Protein B is a nuclear receptor protein that belongs to the NR3 subfamily. It has an approximate mass of 64 kDa. This protein is predominantly expressed in tissues such as the brain and kidney. Mechanically NR3B functions as a ligand-activated transcription factor regulating the expression of specific genes. Its structure includes a DNA-binding domain and a ligand-binding domain enabling it to bind to specific DNA sequences and control gene transcription in response to hormonal and other chemical signals.
Biological function summary
As part of the nuclear receptor family NR3B plays a significant role in regulating gene expression in response to hormonal changes. It forms a complex with other proteins to modulate transcriptional activity. NR3B participates in the regulation of genes involved in cellular growth differentiation and apoptosis. Its activity can influence various downstream biological processes positioning NR3B as an integral component of cellular homeostasis.
Pathways
NR3B integrates into key pathways controlling metabolic and signaling processes. It is notably involved in the nuclear receptor signaling pathway which plays a central role in regulating genes linked to metabolism and cellular stress. In these pathways it interacts with related nuclear receptors such as NR4A1 and NR4A3 which share similar gene regulatory functions. Through these interactions NR3B contributes to maintaining the delicate balance of cellular responses to internal and external stimuli.
NR3B has associations with certain types of cancer and neurological disorders. It plays a role in tumor growth and progression due to its involvement in cell proliferation and survival pathways. In neurological contexts its expression levels can be linked to neurodegenerative diseases where its regulatory functions may be disrupted. NR3B interacts with proteins like BCL2 and AKT which are key players in both cancer progression and neuronal survival mechanisms highlighting the diverse role of NR3B in disease conditions.