Abcam, ab233965, Anti-CDw75 antibody [LN-1]

Size: 100µg
Mouse Monoclonal ST6GAL1 antibody. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing ST6GAL1 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:LN-1,
Isotype:IgM,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing ST6GAL1 protein. The exact immunogen used to generate this antibody is proprietary information.P15907

Properties and Storage Information:
Form-Liquid, Purification notes-Purified from bioreactor concentrate by PEG precipitation., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDw75 also known as ST6Gal I is a sialyltransferase enzyme. This enzyme adds sialic acid to galactose residues on glycoproteins and glycolipids. Its molecular mass is approximately 45 kDa. This target is expressed in a variety of human tissues including the brain liver and immune system cells such as B-lymphocytes. CDw75 plays a vital role in recognizing and modifying cell surface antigens.
Biological function summary
The glycosylation carried out by CDw75 is essential for cell-cell interaction and adhesion processes. This enzyme is involved in forming specific glycan structures on the cell membrane. It is not part of a larger enzyme complex but functions as an individual glycosyltransferase. The glycans synthesized by CDw75 influence various physiological processes in the immune system neural transmission and liver function.
Pathways
Modification of cell surface antigens is where CDw75 fits into cellular mechanisms. It plays significant roles in the immune response pathway by assisting in immunological recognition. It is related to the glycosylation pathway where it functions alongside proteins like CMP-sialic acid synthetase. CDw75 is also related to proteins involved in the cell signaling pathways due to its role in modifying glycans.
Disruption or changes in CDw75 activity have links to certain cancers and autoimmune diseases. Altered expression patterns of CDw75 are observed in conditions such as lymphoma where it affects tumor cell recognition and metastasis potential. Additionally in autoimmune diseases abnormal glycosylation by CDw75 may interfere with immune cell functions. This enzyme connects to other proteins in these conditions such as CD22 which also participates in B-cell receptor signaling and regulation.