Abcam, ab235456, Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist

Size: 5mg / 25mg
MW 615.48 g/mol, Purity >98%. LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.
Key facts
CAS number:1025967-78-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:615.48 g/mol,
Molecular formula:C29H24Cl2N2O7S,
Nature:Synthetic,
Solubility:DMSO >30 mg/mLEthanol 20 mg/mLInsoluble in water,
Biological description:LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.,
Canonical smiles:CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2CL)C(=O)C4=CC5=C(C=C4)C=CO5)CL,
InChi:InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1,
InChiKey:JFOZKMSJYSPYLN-QHCPKHFHSA-N,
IUPAC Name:(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1917 Lifitegrast. B1917-25 is the same size as the 25 mg size of ab235456.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions