Abcam, ab235947, Anti-PBLD antibody

Size: 100µL
Rabbit Polyclonal PBLD antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PBLD aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PBLD aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P30039

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PBLD also known as Phenazine Biosynthesis-Like Protein Domain is a protein with an approximate mass of 40 kDa. It is expressed in various tissues including the liver and kidney. PBLD possesses structural domains that resemble those found in the phenazine biosynthesis family suggesting its involvement in redox processes. Researchers have yet to fully clarify its mechanical role but its conserved domains hint at significant enzymatic functions in cellular metabolism.
Biological function summary
The role of PBLD appears linked to modulation of oxidative stress responses and metabolic processes. PBLD is part of larger protein complexes that regulate intracellular metabolic pathways. Its involvement in these complexes enables it to impact cellular balance in response to environmental or cellular stresses. This function suggests a protective role in maintaining cellular homeostasis and potentially implicates PBLD in detoxification processes within the cell.
Pathways
PBLD participates in metabolic and oxidative stress response pathways specifically the glutathione metabolism and the pentose phosphate pathway. It interacts with other proteins involved in these processes such as NADPH-producing enzymes and components of the oxidative defense system. These interactions allow PBLD to contribute to cellular redox balance and metabolic flux connecting it to essential cellular functions.
PBLD has shown associations with liver disorders and certain metabolic syndromes. For example altered expression of PBLD may relate to hepatic steatosis in conjunction with proteins such as CYP450 enzymes affecting liver metabolism. It also exhibits potential connections to metabolic syndrome where it might influence pathways involving insulin resistance and lipid metabolism indicating its broader role in metabolic health conditions.