Abcam, ab150847, Anti-RICS antibody

Size: 100µL
Rabbit Polyclonal RICS antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP32 aa 1950 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP32 aa 1950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.A7KAX9

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RICS also known as Rho GTPase-activating protein RICS or PX-RICS is a protein that functions as a GTPase-activating protein (GAP) for the Rho family of GTPases. It has a molecular mass of around 120 kDa. Expressed in neurons in the brain RICS regulates signaling pathways by inactivating Rho GTPases which are key for cytoskeletal organization and cell signaling.
Biological function summary
RICS plays an important role in neuronal development and synaptic function. RICS is part of a protein complex that interacts with scaffolding proteins such as PSD-95 which is important for synaptic stability and plasticity. By modulating Rho GTPase activity RICS influences intracellular signaling which impacts cytoskeletal dynamics and receptor trafficking.
Pathways
RICS is involved in the regulation of signaling cascades such as the Wnt and Nogo pathways. It relates to proteins like Dishevelled in the Wnt pathway which regulates neuronal growth and differentiation. In the Nogo pathway RICS partners with proteins like Nogo receptor which limits axon regeneration and growth. These pathways illustrate how RICS modulates neuron structure and connectivity.
RICS has connections to conditions like autism spectrum disorders (ASD) and schizophrenia. RICS interacts with proteins such as DISC1 linked to schizophrenia and changes in RICS expression or activity might contribute to synaptic dysfunction observed in these disorders. RICS impacts cytoskeletal dynamics and receptor localization influencing cognitive and behavioral phenotypes in affected individuals.