Abcam, ab220029, Anti-FoxJ1 antibody [CL3991]

Size: 100µL
Mouse Monoclonal FOXJ1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXJ1 aa 150-350.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CL3991,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FOXJ1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q92949,
Epitope:Binds to an epitope located within the peptide sequence GFWRIDPQYA (aa 193-202) as determined by overlapping synthetic peptides.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FoxJ1 also known as Forkhead Box J1 is a transcription factor that plays an important role in the regulation of gene expression. It is part of the forkhead family of transcription factors and has a molecular mass of approximately 44 kDa. FoxJ1 is expressed mainly in tissues with motile cilia such as the brain respiratory tract and reproductive organs. This expression pattern highlights its significance in tissues where ciliary movement is important for normal function.
Biological function summary
FoxJ1 is important in ciliogenesis the process of building cilia on the surface of cells. It acts as a master regulator by activating genes that code for ciliary components. This includes genes involved in the formation of the axoneme the core structure of cilia. FoxJ1 does not work alone; it functions within a network of other transcription factors and proteins to achieve effective cilia formation and movement. By controlling this process FoxJ1 ensures that ciliary structures develop and function correctly which is necessary for cellular motility and fluid movement across epithelial surfaces.
Pathways
FoxJ1 operates within critical pathways involved in cilia development and function. It integrates into the Wnt signaling pathway which is critical for embryogenesis and cell polarity. Additionally FoxJ1 interacts with the Notch signaling pathway. In these pathways it can relate to other transcription factors like Rfx3 which also influence cilia-related gene expression. FoxJ1 coordinates with these pathways to ensure precise regulation of cilia biogenesis and maintenance contributing to cellular processes that depend on functional cilia.
Deficient or malfunctioning FoxJ1 can lead to primary ciliary dyskinesia (PCD) and respiratory diseases. PCD results from impaired ciliary movement affecting respiratory tract function and fertility. Dysfunctional FoxJ1 expression can disrupt ciliary architecture connecting it to other proteins like DNAI1 which is often implicated in PCD. Abnormal FoxJ1 activity has also been linked to hydrocephalus where cerebrospinal fluid imbalances occur due to faulty cilia movement. In these conditions understanding FoxJ1's role provides insight into potential targets for therapeutic interventions.