Abcam, ab237539, Anti-24p3R antibody

Size: 100µL
Rabbit Polyclonal 24p3R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC22A17 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC22A17 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8WUG5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 24p3R also known as SLC22A17 or neutrophil gelatinase-associated lipocalin receptor is a receptor protein that facilitates cellular uptake of its ligand the neutrophil gelatinase-associated lipocalin (NGAL) known scientifically as lipocalin-2. This receptor with a molecular mass of approximately 55 kDa participates in iron regulation by binding and internalizing iron-laden NGAL. Expression of 24p3R occurs across various tissues with significant presence in kidney liver and spleen reflecting its systemic role in iron homeostasis.
Biological function summary
The NGAL and 24p3R interaction plays a critical role in iron metabolism and immune response. The receptor delivers NGAL-bound iron to cells impacting the cell's iron availability an essential process for many cellular functions and maintaining systemic iron balance. This interaction does not occur in isolation; 24p3R operates within a larger complex network involving other iron-regulating proteins like transferrin which collectively orchestrate iron absorption distribution and storage in the body.
Pathways
24p3R functions within the iron metabolism pathway essential for iron uptake and regulation. Its interaction with NGAL is related to the transferrin receptor pathway which regulates iron uptake through transferrin-bound iron. These interactions highlight the role of 24p3R beyond the basic cellular uptake of NGAL influencing systemic iron distribution and maintaining cellular iron homeostasis. Proteins like transferrin family members modulate this pathway and are integral to the function of 24p3R in cellular iron control.
24p3R involvement is directly linked to conditions characterized by iron imbalance such as iron deficiency anemia and chronic kidney disease. Aberrant expression or function of 24p3R can contribute to these diseases through disturbed iron metabolism. In these contexts NGAL levels often elevated act as markers of disrupted iron homeostasis and inflammation further associating 24p3R with the pathological processes. By connecting with NGAL 24p3R plays a role in these diseases highlighting its importance in maintaining iron equilibrium in health and disease.