Abcam, ab100983, Recombinant Human GMPR2 protein

Size: 50µg / 250µg
Recombinant Human GMPR2 protein is a Human Full Length protein, in the 1 to 348 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9P2T1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GMPR2 protein also known as Guanosine Monophosphate Reductase 2 plays an important role in nucleotide metabolism by converting guanosine monophosphate (GMP) into inosine monophosphate (IMP). This enzyme has a molecular weight of approximately 38 kDa and operates similarly to other members of the IMPDH/GMPR family. GMPR2 expression occurs in various tissues although it is especially active in those requiring active nucleotide turnover like the liver and lymphoid tissues. Its enzymatic activity contributes to maintaining a balanced supply of nucleotides within the cell.
Biological function summary
GMPR2 influences purine nucleotide metabolism which impacts cellular proliferation and differentiation processes. This protein does not operate alone; it frequently associates with other enzymes in nucleotide synthesis and degradation pathways ensuring efficient metabolic flow. By modulating the concentrations of GMP and IMP GMPR2 directly affects the synthesis of critical nucleic acids and energy carriers in the cell. This control is essential for cells undergoing rapid growth or engagement in vigorous metabolic activities.
Pathways
GMPR2 functions within the salvage and de novo pathways of purine metabolism. It plays a significant role in the salvage pathway by recycling guanosine nucleotides which complements the actions of enzymes like IMP dehydrogenase. Together these proteins ensure proper cellular nucleotide levels important for DNA/RNA synthesis and cell signaling. This coordination within the pathways highlights GMPR2's importance in maintaining cellular health and function.
GMPR2 has connections to cancer and immunodeficiency. Altered GMPR2 activity can disrupt nucleotide balance potentially contributing to the uncontrolled cell proliferation observed in cancers. Additionally shifts in nucleotide metabolism may impair immune cell function leading to immunodeficiency conditions. In these contexts proteins like GMP synthase may interact with GMPR2 influencing the disease outcome due to their shared roles in nucleotide metabolism. Understanding these interactions provides further insight into GMPR2's relevance in health and disease contexts.