Abcam, ab101778, Recombinant human Eph receptor A1/EphA1 protein

Size: 5µg / 10µg
Recombinant human Eph receptor A1/EphA1 protein is a Human Fragment protein, in the 569 to 976 aa range, expressed in Baculovirus, with >90%, suitable for WB, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus,
Tags:Tag free,
Applications:FuncS, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The Specific activity of ab101778 was determined to be 28 nmol/min/mg.,
Accession:P21709,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.307% Glutathione, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00292% EDTA, 0.00174% PMSF

Product details:
ab204877
(Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity
Previously labelled as Eph receptor A1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Eph receptor A1 also known by the alternative name EphA1 is a member of the ephrin receptor family part of the larger group of receptor tyrosine kinases. The EphA1 protein carries a molecular mass of approximately 108 kDa. Mechanically it functions as a cellular signaling molecule by binding ephrins its membrane-bound ligands which initiates bidirectional signaling pathways. This interaction typically occurs at cell-cell interfaces involving dynamic communication essential for cellular processes. EphA1 is expressed in a variety of tissues with a significant presence in epithelial tissues where it plays roles in maintaining tissue architecture.
Biological function summary
EphA1 contributes to cellular adhesion migration and positioning linking to ephrin ligands to form signaling complexes. These complexes aid in regulating developmental processes such as angiogenesis and neuronal development by transmitting signals that control cell shape and movement. The EphA1 receptor also influences cell proliferation and plays a role in the inhibition of cell migration by responding to concentration gradients of ephrin ligands. Its ability to control cellular boundaries and morphology highlights its importance in tissue patterning and organogenesis.
Pathways
EphA1 integrates into the Eph/ephrin signaling pathway a critical framework for developmental processes and cellular organization. This pathway involves cross-talk with the MAPK signaling cascade which further influences cell proliferation and differentiation. The interplay between EphA1 and other Eph receptors like EphB2 enhances bidirectional signaling that accommodates both forward and reverse signal transduction a feature that accommodates dynamic cellular responses in development and homeostasis.
EphA1 has significant connections to cancer progression and metastasis particularly in colorectal carcinoma and melanoma. Alterations in EphA1 expression can lead to deregulated cellular pathways contributing to tumor development and spread. EphA1's relationship with proteins like ephrin A1 and other Eph receptors such as EphA2 provides a link between its dysregulation and cancer pathology highlighting its potential as a therapeutic target in oncology.