Abcam, ab102575, Anti-MTMR14 antibody

Size: 50µL
Rabbit Polyclonal MTMR14 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTMR14 aa 250-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTMR14 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.Q8NCE2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTMR14 also known as Jumpy or KIAA0788 is a member of the myotubularin-related protein family. This protein functions as a phosphatase where it dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 35-bisphosphate (PI(35)P2). MTMR14 has a molecular mass of approximately 87 kDa. Researchers find its expression in various tissues with substantial levels in muscle and brain tissue.
Biological function summary
MTMR14 plays a role in maintaining intracellular membrane dynamics. It forms part of a complex with other myotubularins which regulate phosphoinositide levels. By modulating these lipids MTMR14 helps control endocytosis autophagy and membrane trafficking. This regulation is essential for normal cellular function and homeostasis.
Pathways
MTMR14 is involved in the PI3K-Akt signaling pathway and the phosphatidylinositol signaling system. It interacts with proteins like Akt and mTOR influencing cellular processes such as growth and metabolism. These pathways are important for cell survival growth and differentiation demonstrating MTMR14's role in comprehensive cellular functions.
MTMR14's dysfunction links to conditions like centronuclear myopathy and Charcot-Marie-Tooth disease. These disorders result from mutations impacting MTMR14's phosphatase activity. MTMR14 interacts with other proteins such as dynamin 2 in these conditions highlighting its relevance to disease pathogenesis and potential as a therapeutic target.