Abcam, ab10352, Anti-NPFF antibody

Size: 50µL
Rabbit Polyclonal NPFF antibody. Suitable for IHC-Fr and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Pro-FMRFamide-related neuropeptide FF. The exact immunogen used to generate this antibody is proprietary information.O15130

Product details:
Phe Met Arg Phe-NH2, a tetrapeptide neurotransmitter, a member of the same family of RFamide peptides as FLRFamide, sharing the same C terminal RFamide sequence. FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL Gene encodes a preproprotein where upon cleavage forms two active peptides possessing similar function.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuropeptide FF (NPFF) also known as FMRFamide-related peptide acts as a significant neuromodulator in the nervous system. NPFF weighs approximately 1200 daltons and appears in high concentrations in the central nervous system particularly in the spinal cord and hypothalamus. This peptide belongs to the RFamide family of neuropeptides. Researchers have identified RFamide peptides for roles in pain modulation and various autonomic processes.
Biological function summary
The RFamide neuropeptides including NPFF influence pain perception and analgesia. NPFF does not explicitly form part of a complex but it interacts closely with specific receptors namely NPFF1 and NPFF2. These receptors mediate the diverse physiological responses induced by NPFF. Studies demonstrate NPFF's capability to inhibit the effects of opioids highlighting its involvement in the body's pain-control network.
Pathways
The NPFF system plays a role in multiple signaling cascades connected to pain and stress responses. NPFF engages in the opioid receptor pathways impacting how the body processes discomfort and analgesics. Several interactions link NPFF to proteins like opioid receptors and adrenal corticotropic hormone (ACTH). These interactions help regulate the body's response to pain stress and hormone release.
NPFF connections to pain-related conditions and opioid dependency emerge as important research areas. The modulation of opioid effects by NPFF highlights its potential link to the mechanisms of opioid addiction. Additionally NPFF associations with chronic pain disorders suggest a possible therapeutic target. The dynamic between NPFF its receptors and opioid receptors characterizes the complex interplay affecting pain management and addiction response.