Abcam, ab1044, Anti-p13 antibody [BM3]

Size: 100µg
Mouse Monoclonal CSL4 antibody. Suitable for ELISA and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BM3,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This protein A purified mouse monoclonal antibody reacts specifically with p13 in human granulocytes and monocytes residing in lymphoid and non-lymphoid tissues The antibody recognizes a 13 kDa band corresponding to p13. Cross reactivity from other sources has not been determined.

Product details:
BM3 is an early marker of myeloid differentiation. Immunoprecipitation experiments using S35 methionine labeled human myeloid leukemia cells show that BM3 identifies a 13 kDa protein.
The antibody does not stain tissue after paraffin treatment.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-This protein A purified mouse monoclonal antibody reacts specifically with p13 in human granulocytes and monocytes residing in lymphoid and non-lymphoid tissues., Storage buffer-pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P13 also known as MAPK-interacting serine/threonine-protein kinase 1 (MNK1) is a protein with a mass of approximately 51 kDa. This protein functions as a kinase meaning it adds phosphate groups to other molecules often regulating their activity. p13 is expressed in various tissues but it shows higher expression in the brain and testes. Like many kinases it modulates cellular processes by phosphorylating substrates which leads to changes in their function and consequently impacts cell signaling pathways.
Biological function summary
The kinase activity of p13 influences several processes by participating in the regulation of mRNA translation. It binds to and phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) which is a component of the eIF4F complex responsible for initiating protein synthesis. By phosphorylating eIF4E p13 affects translation rates and potentially influences the production of proteins from specific mRNAs thereby indirectly controlling various cellular functions.
Pathways
P13 plays roles in the mitogen-activated protein kinase (MAPK) signaling and mammalian target of rapamycin (mTOR) pathways. These pathways regulate cell growth proliferation and survival. In the MAPK pathway p13 can interact with various other kinases such as ERK and integrate signals that influence translation. The mTOR pathway involves complex signaling networks where p13 modulates translation machinery components. Through these pathways p13 interconnects with proteins like RPS6KB1 further illustrating its role in controlling protein synthesis and cellular growth.
P13 has been linked to cancer and neurodegenerative diseases. In cancer its elevated activity may lead to increased protein synthesis and cell proliferation contributing to tumorigenesis. For instance its interplay with eIF4E has been observed in several malignancies suggesting a potential therapeutic target in oncology. In neurodegenerative diseases aberrant signaling involving p13 may alter neuron function or survival possibly involving proteins like mTOR which when dysregulated contribute to the pathophysiology of conditions like Alzheimer's disease.