Abcam, ab106456, Anti-JMJD1A antibody

Size: 100µg
Rabbit Polyclonal KDM3A / JHDM2A antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human KDM3A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KDM3A. The exact immunogen used to generate this antibody is proprietary information.Q9Y4C1,
Specificity:ab106456 does not not cross-react with JMJD1B or JMJD1C.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab106456 is purified by affinity chromatography via a peptide column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JMJD1A also known as KDM3A is a histone demethylase that belongs to the Jumonji C (JmjC) domain-containing family. This enzyme removes methyl groups from mono- and dimethylated lysine 9 on histone H3 impacting chromatin structure and gene expression. The molecular mass of JMJD1A is approximately 147 kDa. High expression levels of JMJD1A are found in several tissues including the testis suggesting its role in reproductive biology. There is also expression in various other tissues indicating its involvement in diverse biological processes.
Biological function summary
JMJD1A plays important roles in regulating gene transcription by altering chromatin states. It influences processes associated with oxygen sensing metabolism and cell cycle regulation. Although not conformed as an integral part of a multi-protein complex it often collaborates with transcription factors to achieve precise regulatory functions. This interaction modulates various downstream effects on cell differentiation proliferation and apoptosis.
Pathways
JMJD1A functions mainly in the hypoxia-signaling pathway and also intersects with metabolic regulation. It acts in concert with hypoxia-inducible factor 1 alpha (HIF-1α) to respond to changes in oxygen levels. This positioning places JMJD1A in a network with other histone demethylases like JMJD2A where they collectively modulate complex genetic programs under hypoxic conditions. Furthermore JMJD1A's role in metabolic pathways links it with proteins involved in energy homeostasis like peroxisome proliferator-activated receptor gamma (PPARγ).
JMJD1A has notable associations with cancer and obesity. In several cancer types increased JMJD1A activity elevates expressions of genes that promote tumorigenesis suggesting a contributory role in cancer progression. Its interactions with oncogenic proteins like c-Myc further highlight its significance in malignancies. With obesity JMJD1A correlates with altered metabolic regulation influencing fat deposition and insulin sensitivity. The pathway links to other metabolic regulators such as liver X receptor alpha (LXRα) underline its involvement in metabolic disorders.