Abcam, ab106553, Anti-ARHGAP18 antibody

Size: 100µg
Rabbit Polyclonal ARHGAP18 antibody. Suitable for ICC, WB, ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Rho GTPase-activating protein 18.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, ICC, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Rho GTPase-activating protein 18. The exact immunogen used to generate this antibody is proprietary information.Q8N392,
Specificity:At least two isoforms of ARHGAP18 are known to exist; ab106553 with detect both isoforms. ab106553 will not cross-react with other ARHGAP family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP18 also known as Rho GTPase Activating Protein 18 is a protein that plays a role in regulating the actin cytoskeleton. It is part of the larger family of Rho GTPase-activating proteins (GAPs) and has a molecular mass of approximately 57 kDa. ARHGAP18 is expressed in various tissues including the liver and lung indicating its importance in different cellular contexts.
Biological function summary
ARHGAP18 influences cell shape and motility by modulating the Rho signaling pathway. It acts as a negative regulator of RhoA activity thereby impacting actin filament organization. The protein does not form large complexes but interacts with other cytoskeleton-associated proteins to exert its effects on cell structure and movement.
Pathways
ARHGAP18 is involved in the regulation of the RhoA signaling pathway which is essential for cell movement and growth. This protein interacts with other Rho GTPases to maintain cellular architecture and coordination during cellular processes. Notably it participates in pathways that control the dynamics of the actin cytoskeleton aligning with proteins such as ROCK1 and ROCK2.
ARHGAP18 has been linked to the progression of cancer and cardiovascular diseases. Abnormal expression of ARHGAP18 can lead to irregularities in cell migration and invasion contributing to cancer metastasis. In cardiovascular disorders it interacts with proteins such as RhoA and involves in the pathogenesis of atherosclerosis by affecting vascular smooth muscle cell function.