Abcam, ab106561, Anti-CALHM1 antibody

Size: 100µg
Rabbit Polyclonal CALHM1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CALHM1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CALHM1. The exact immunogen used to generate this antibody is proprietary information.Q8IU99,
Specificity:This antibody is predicted to not crossreact with CALHM2 or CALHM3.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CALHM1 also known as Calcium Homeostasis Modulator 1 functions as a channel involved in calcium regulation across cell membranes. It has a mass of approximately 30 kDa. Researchers find CALHM1 predominantly expressed in the nervous system particularly in neurons of the central nervous system. It plays an important role in mediating Ca2+ influx which is essential for various cellular activities.
Biological function summary
CALHM1 modulates key signaling pathways by forming a large pore channel complex. This complex allows not only calcium ions but also ATP to pass through facilitating extracellular communication and signal transduction. Through these activities CALHM1 impacts synaptic transmission and neuronal excitability influencing overall neuronal communication.
Pathways
The modulation of calcium signaling by CALHM1 connects closely to the purinergic signaling pathway and the amyloid precursor protein (APP) metabolism pathway. It exhibits interaction with proteins related to these pathways such as APP itself and P2X receptors which are involved in purinergic signaling. CALHM1 therefore bridges critical cellular processes that govern calcium homeostasis and energy coupling.
Studies associate CALHM1 with neurodegenerative conditions such as Alzheimer's disease. Altered function of CALHM1 can impact APP processing linked to Alzheimer's pathology. CALHM1's interaction with APP suggests that dysregulation of its channel activity could contribute to the pathogenesis of the disease. Understanding the relation between CALHM1 and these proteins may offer insights into potential therapeutic targets for neurological disorders.