Abcam, ab106586, Anti-ZIP-13 antibody

Size: 100µg
Rabbit Polyclonal ZIP-13 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A13.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC39A13. The exact immunogen used to generate this antibody is proprietary information.Q96H72,
Specificity:At least two isoforms of ZIP-13 are known to exist; ab106586 will detect both isoforms. ab106586 is predicted to not crossreact with other ZIP family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZIP-13 also known as Zrt- and Irt-like protein 13 or SLC39A13 is a member of the ZIP family of metal ion transporters. It has a molecular weight of about 34 kDa. ZIP-13 functions by importing zinc and iron into cells therefore maintaining cellular metal ion homeostasis. Researchers have found the expression of ZIP-13 in various tissues including skin bone and connective tissues.
Biological function summary
ZIP-13 plays an important role in processes such as development and differentiation. It does not work as part of any known complex but facilitates important cellular functions by ensuring the balance of zinc and iron ions necessary for enzymatic and structural roles in cells. The activity of ZIP-13 has significant implications for the synthesis of proteins and signaling pathways that depend on zinc.
Pathways
ZIP-13 influences important biological cascades including the TGF-beta signaling and BMP signaling pathways which are important for bone and tissue development. ZIP-13 is related to proteins like SMAD4 and BMP receptors through these pathways. By regulating metal ion concentration ZIP-13 indirectly affects downstream elements in these signaling cascades.
ZIP-13 has associations with conditions such as Ehlers-Danlos syndrome and spondylodysplastic types. Mutations or dysregulation in ZIP-13 can lead to abnormalities in connective tissue formation and maintenance. In Ehlers-Danlos syndrome ZIP-13's interaction with proteins involved in collagen synthesis such as COL1A1 is of particular importance contributing to symptomatic presentations in affected individuals.