Abcam, ab106628, Anti-ZBTB9 antibody

Size: 100µg
Rabbit Polyclonal ZBTB9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 9. The exact immunogen used to generate this antibody is proprietary information.Q96C00,
Specificity:ab106628 is predicted to not cross-react with other ZBTB family members

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab106628 is purified by affinity chromatography via a peptide column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZBTB9 also known as Zinc Finger and BTB Domain-Containing Protein 9 is a transcription factor involved in gene expression regulation. It has an approximate mass of 56 kDa. The protein contains a conserved C2H2-type zinc finger domain which allows it to bind specific DNA sequences and modulate transcription. ZBTB9 is mainly expressed in the human brain and various tissues indicating a broad role in physiological processes. This protein's activity is essential for the regulation of genes involved in numerous cellular functions.
Biological function summary
Expertise in transcription regulation reveals ZBTB9 as a significant player. It often functions individually but can associate with other proteins to form complexes that may influence its role in transcription repression or activation. ZBTB9 interacts with different transcriptional co-repressors and co-activators to control the expression of target genes involved in cell cycle regulation apoptosis and differentiation. This precise gene regulation allows the cell to respond to various developmental and external stimuli maintaining cellular homeostasis.
Pathways
Current studies connect ZBTB9 to important transcriptional pathways like the Wnt signaling path and the cell cycle control path. In the Wnt pathway ZBTB9 interacts with proteins such as β-catenin to modulate gene expression important for cell proliferation and differentiation. In the cell cycle path it may interact with key regulators like cyclins and CDKs to influence cell division ensuring proper cell cycle progression and arrest when necessary. These interactions place ZBTB9 as a pivotal mediator in pathways affecting cellular growth and development.
Understanding the connection of ZBTB9 to pathological conditions can provide insights into its clinical significance. ZBTB9 has shown relevance in neurodegenerative diseases particularly Alzheimer's disease due to its expression in the brain and association with neural cell functions. It also appears in studies related to cancer biology with connections to proteins such as p53 indicating a role in tumorigenesis processes like cell cycle dysregulation and apoptosis resistance. These associations suggest that ZBTB9 could be a potential target for therapeutic strategies in diseases where its pathways and interactions are disrupted.