Abcam, ab106630, Anti-GSAP antibody

Size: 100µg
Rabbit Polyclonal GSAP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human GSAP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GSAP. The exact immunogen used to generate this antibody is proprietary information.A4D1B5,
Specificity:ab106630 is predicted to not cross-react with other F-box protein family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab106630 was purified by affinity chromatography via a peptide column., Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gamma-secretase activating protein (GSAP) is a critical regulator in the modulation of gamma-secretase activity influencing the production of amyloid beta-peptides. Also known by its alternative name GSAP the protein has a molecular mass of approximately 16 kDa. It is expressed in multiple tissues including the brain where its presence is significant due to its involvement in neurobiological processes.
Biological function summary
GSAP interacts mechanically with gamma-secretase and enhances its specificity for amyloid precursor protein (APP). This interaction plays a significant role in amyloidogenic processes and is part of a larger complex impacting the generation of amyloid beta-peptides. Through this interaction GSAP becomes an important factor in the regulation of pathways related to amyloid beta generation.
Pathways
GSAP actively participates in the amyloidogenic pathway which is pivotal in Alzheimer's disease pathology. In the context of this pathway GSAP closely interacts with gamma-secretase complex components including presenilins which significantly influence beta-amyloid levels. Likewise GSAP's interaction with APP reflects on its integral role in modulating the proteolytic cascade that generates beta-amyloid peptides.
GSAP's role is most notably linked to Alzheimer's disease. Its contribution to the production of beta-amyloid peptides positions it centrally in the pathogenesis of Alzheimer's wherein these peptides aggregate to form neurotoxic plaques. The interaction with presenilin proteins further ties GSAP to familial forms of Alzheimer's disease reinforcing its potential as a therapeutic target in mitigating such neurodegenerative disorders.