Abcam, ab106713, Anti-Mael antibody

Size: 100µg
Rabbit Polyclonal MAEL antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MAEL.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAEL. The exact immunogen used to generate this antibody is proprietary information.Q96JY0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mael also known as Maelstrom is a protein associated with the Piwi-interacting RNA (piRNA) pathway. This protein has a mass of approximately 52 kDa. Mael is mainly expressed in germ cells where it contributes to spermatogenesis. It acts as an important component of the piRNA pathway which is important to defend the genome integrity in germline cells against transposable elements. Its function is essential for germ cell development and integrity.
Biological function summary
Maelstrom interacts with other proteins to form a complex necessary for the piRNA biogenesis. This complex aids in the silencing of transposable elements to protect germ cell DNA from damage. Understanding Mael's role within the piRNA pathway highlights its significance in regulating genomic stability. It acts in coordination with other piRNA pathway proteins like Piwi and Tudor domain proteins to ensure effective transposon silencing. These interactions emphasize Mael’s importance for maintaining the stability of genetic information passed to the next generation.
Pathways
Mael plays an integral part in the piRNA-mediated silencing pathway. It participates in piRNA biogenesis an important pathway involved in post-transcriptional regulation of gene expression in the germline. Mael has a relation to other pathway-associated proteins such as Ago (Argonaute proteins) and Piwi proteins which are fundamental for transcriptional silencing and transposon control. This association with piRNA machinery highlights Mael's role in safeguarding gamete DNA from transposon-induced mutations.
Research indicates that Mael contributes to infertility linked with anomalies in spermatogenesis. Aberrant function or expression of Mael can lead to defective piRNA processing which compromises genome integrity and results in infertility. Its link with proteins like Piwi proteins in regulating transposons also suggests a potential connection to testicular cancer as disruptions in piRNA pathways can contribute to oncogenic processes within germ cells. Investigating Mael and its interactions provides insights into therapeutic approaches for treating such reproductive disorders.