Abcam, ab107134, Recombinant Human SNRPB2 protein

Size: 50µg / 250µg
Recombinant Human SNRPB2 protein is a Human Full Length protein, in the 1 to 225 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P08579,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 40% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNRPB2 also known as small nuclear ribonucleoprotein polypeptide B' is a protein that plays a role in the splicing of pre-mRNA. It often weighs around 25 kDa and is expressed in the nucleus of cells. The protein is a component of the spliceosome which is an essential part of the RNA processing machinery in eukaryotic cells. In particular SNRPB2 is part of the U2 small nuclear ribonucleoprotein (snRNP) complex acting in spliceosome assembly and RNA splicing events.
Biological function summary
Proteins like SNRPB2 contribute to the regulation of gene expression by ensuring the accurate removal of introns from precursor mRNA. SNRPB2 exists as part of the U2 snRNP an important component of the spliceosome. This complex participates in recognizing the splicing sites and catalyzing the chemical reactions necessary for intron excision. Therefore SNRPB2 along with other proteins and RNA molecules within the spliceosome guarantees precise RNA maturation which is necessary for correct protein synthesis in eukaryotic cells.
Pathways
RNA splicing machinery like the spliceosome featuring SNRPB2 engages in the RNA processing pathway. This protein often works alongside U1 snRNP and is also interconnected with mRNA surveillance mechanisms ensuring that errors in RNA transcripts are recognized and degraded. Importantly SNRPB2 has relationships with other spliceosome components such as SF3A and SF3B that also ensure the fidelity of the splicing process and its integration with various cellular signaling pathways.
Mutations or malfunctions in SNRPB2 have links with conditions like retinitis pigmentosa and spinal muscular atrophy. These genetic disorders often stem from disruptions in the normal splicing processes that are essential for nerve and photoreceptor cell function. In these disorders connections have been made between SNRPB2 and other related proteins such as SMN1 in spinal muscular atrophy further illustrating the complexity of its involvement in maintaining healthy cellular function and gene expression.