Abcam, ab108991, Anti-TRAF4 antibody [EPR1729]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRAF4 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1729,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRAF4 also known as Tumor Necrosis Factor Receptor-Associated Factor 4 is a scaffold protein with a molecular weight of approximately 55 kDa. TRAF4 interacts with a variety of intracellular signaling molecules influencing signal transduction. It is expressed prominently in epithelial cells and the respiratory tract reflecting its involvement in tissue homeostasis and cell communication. The protein contains a conserved RING finger domain a novel zinc finger TRAF-type domain and a coiled-coil region which are essential for its function in protein-protein interactions.
Biological function summary
TRAF4 participates in the regulation of immune responses and development of epithelial tissues. This protein modulates signaling pathways by promoting or inhibiting the activation of transcription factors including NF-κB and AP-1 which are critical for the immune system's function. TRAF4 associates with various adapter proteins forming signaling complexes that influence cellular outcomes during immune responses. It also plays a role in the development and integrity of the respiratory epithelium highlighting its importance in maintaining epithelial barrier functions.
Pathways
TRAF4 integrates into the TNF receptor signaling pathway and the TGF-beta signaling pathway. In the TNF receptor pathway TRAF4 interacts with other TRAF family members mediating responses to inflammatory cytokines and regulating apoptosis. Within the TGF-beta pathway TRAF4 modulates signal transduction involving Smad proteins impacting cellular growth and differentiation. The protein's role within these pathways highlights its capacity to influence both immune responses and tissue homeostasis.
TRAF4 has associations with cancer progression and chronic inflammatory diseases. Altered expression levels of TRAF4 can contribute to tumorigenesis by affecting cell survival and proliferation involving interaction with proteins like NF-κB and TGF-beta receptors. In chronic inflammatory diseases TRAF4's dysregulation can exacerbate inflammation through pathways that involve interactions with cytokines and other TRAF family proteins. TRAF4 represents a potential target for therapeutic intervention aiming to modulate immune responses and ameliorate disease symptoms.