Abcam, ab109173, Anti-Pbx3 antibody [EPR2833(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PBX3 antibody. Suitable for WB and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2833(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pbx3 also known as pre-B-cell leukemia transcription factor 3 is a transcription factor that belongs to the TALE/PBX homeobox family. It has an approximate mass of 47 kDa and usually expresses in tissues such as the brain and the pancreas. Mechanically Pbx3 regulates gene expression by binding to specific DNA sequences and forming complexes with other transcription factors. Its function is important for the transcriptional regulation process during developmental stages.
Biological function summary
Pbx3 plays a significant role in the development of several tissues including the central nervous system. It frequently associates with other proteins like Meis1 and HoxB1 to form transcriptional complexes that regulate essential genes involved in cell differentiation and organogenesis. These complexes mediate the control of target gene activity ensuring proper embryonic development and cellular differentiation.
Pathways
Pbx3 participates in critical regulatory networks such as the retinoic acid signaling pathway and the hematopoietic stem cell differentiation pathway. In these pathways Pbx3 acts in conjunction with proteins like Hox genes and Meis proteins influencing the transcriptional regulation important for tissue specification and stem cell renewal. This functional interaction allows Pbx3 to contribute significantly to developmental processes and cellular programming.
Pbx3 has significant implications in conditions like acute lymphoblastic leukemia and diabetes mellitus. In acute lymphoblastic leukemia Pbx3 interacts with oncogenic fusion proteins such as E2A-Pbx1 contributing to the malignancy's development by altering normal transcriptional regulation. In diabetes its expression levels affect pancreatic development and insulin regulation linking it to metabolic disturbances associated with the disorder.