Abcam, ab109442, Anti-p60 CAF1/MPP7 antibody [EPR6105]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal p60 CAF1/MPP7 antibody. Suitable for IHC-P, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6105,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target p60 CAF1/MPP7 also known simply as MPP7 is a protein involved in cellular mechanisms regarding chromatin assembly. It has a mass of approximately 55 kDa. Expression of MPP7 occurs predominantly in the cytoplasm and nucleus. Its function involves association with chromatin assembly factor 1 (CAF-1) complex hence the name p60 CAF1 highlighting its role in DNA replication and repair processes.
Biological function summary
In cellular environments MPP7 is significant in maintaining cell polarity and epithelial cell junctions. It plays an important part in forming the Crumbs-3 (CRB3) complex an essential component regulating epithelial cell polarity. Through this complex MPP7 collaborates closely with PATJ (Pals1-associated tight junction protein) and DLG1 (Discs Large Homolog 1) contributing to cell junction stability and signal transduction pathways that regulate epithelial integrity.
Pathways
MPP7 is integral to epithelial cell polarity pathways and cell adhesion signaling. It affects pathway activities by coordinating with proteins like DLG1 and PATJ. By aligning with the CRB3 complex MPP7 influences processes within the Hippo signaling pathway a pathway that controls cell proliferation and apoptosis. This positions MPP7 as a mediator balancing cell growth and communication in complex signaling networks.
MPP7 links to cancer progression and epithelial tissue-related conditions. Due to its role in maintaining cell polarity and structure alterations or disruptions in MPP7 functions could contribute to tumorigenesis. This connection emerges through interactions with PATJ and DLG1 impacting the integrity of epithelial junctions also potentially influencing conditions like Inflammatory Bowel Disease (IBD) where epithelial barrier function is important. Research continues to elucidate the exact mechanisms opening paths for therapeutic targeting in these diseases.