Abcam, ab109502, Anti-Proteasome 20S alpha 2/HC3 antibody [EPR5454]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Proteasome 20S alpha 2/HC3 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5454,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Proteasome 20S alpha 2 also known as HC3 forms part of the proteasome complex responsible for protein degradation. This protein has a molecular mass of approximately 25 kDa and functions as a structural component of the 20S core particle within the proteasome. The 20S alpha 2 subunit is highly conserved and expressed in various tissues contributing to cellular protein homeostasis through the removal of damaged or misfolded proteins.
Biological function summary
The 20S alpha 2 subunit integrates into the larger 26S proteasome complex working alongside other subunits to regulate protein turnover. This complex controls the degradation of ubiquitin-tagged proteins impacting diverse cellular processes like cell cycle progression and stress response. Through its role in the proteasome HC3 maintains protein quality control within the cell and supports proper cellular function.
Pathways
Proteasome 20S alpha 2 interacts within the ubiquitin-proteasome pathway and plays a central role in protein degradation and turnover. It associates with related proteins such as other members of the proteolytic complex and interacts with ubiquitin ligases to efficiently process and degrade proteins tagged for destruction. By facilitating these pathways it is critical for cellular regulation and response to changes.
Proteasome 20S alpha 2 has associations with several pathological conditions including neurodegenerative diseases and cancer. The malfunction or altered expression of this subunit can impact protein degradation contributing to the accumulation of malfunctioning proteins linked to these diseases. It interacts with proteins like p53 in cancer where proteasomal regulation can affect tumorigenesis and with neurofibrillary tangles in Alzheimer's disease affecting neuronal health.