Abcam, ab109622, Anti-INPP4A antibody [EP3425(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal INPP4A antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP3425(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INPP4A also known as inositol polyphosphate 4-phosphatase type I is an enzyme that specifically dephosphorylates the D-4 position phosphate of phosphoinositides. It has a molecular mass of about 105 kDa. This enzyme is expressed in several tissues including brain and platelets indicating its involvement in various cellular processes. INPP4A is significant in controlling the intracellular levels of phosphoinositide messengers and plays an important role in signaling pathways.
Biological function summary
INPP4A functions to regulate phosphoinositide signaling which is critical in controlling cell growth apoptosis and other cellular processes. It acts by reducing levels of phosphatidylinositol 34-bisphosphate an important lipid signaling molecule. INPP4A does not appear to form part of a larger complex but operates within a network of other phosphatases and kinases that together maintain lipid signaling homeostasis.
Pathways
INPP4A interacts mainly in the phosphoinositide 3-kinase (PI3K) signaling pathway. This pathway is important for various cellular functions such as metabolism cell growth and survival. INPP4A modifies the activity of related proteins within this pathway like PI3K by reducing phosphatidylinositol 34-bisphosphate levels therefore controlling downstream signaling. It also connects with other phosphoinositide phosphatases like PTEN to finely tune the signaling balance.
INPP4A is linked to neurological disorders and cancer. In cancer the dysfunction of INPP4A can lead to abnormal cell growth due to dysregulated PI3K signaling. This enzyme's activity is central in maintaining normal phosphoinositide turnover and its interactions with proteins such as PTEN underline its importance in preventing uncontrolled cell proliferation. For neurological disorders alterations in INPP4A function may affect synapse function and neuronal survival contributing to neurodegenerative processes.