Abcam, ab109864, Anti-Adenine Nucleotide Translocase Immunocapture antibody [5F51BB5AG7]

Size: 100µg
Mouse Monoclonal ADT1 antibody. Suitable for IP, IHC-P and reacts with Cow, Human samples. Cited in 5 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:5F51BB5AG7,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Cow, Human,
Applications:IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification notes-ab109864 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adenine nucleotide translocase (ANT) also known as ADP/ATP translocase is a protein that mechanically facilitates the exchange of ATP and ADP across the inner mitochondrial membrane. This exchange is essential for maintaining the mitochondrial membrane potential and energy metabolism. ANT has a molecular mass of approximately 30-33 kDa and is expressed in the mitochondria of virtually all eukaryotic cells where it plays an essential role in energy homeostasis.
Biological function summary
ANT functions as a transporter that is part of the mitochondrial permeability transition pore complex (mPTP). This complex plays an important role in regulating mitochondrial membrane permeability which affects processes like cell death and cellular metabolism. ANT's activity is a significant factor in regulating the mitochondrial functions since it directly influences the ATP supply to the cell.
Pathways
ANT is a core component of the oxidative phosphorylation pathway which is an important biological process for ATP production. In this pathway ANT cooperates closely with other proteins such as cytochrome c oxidase and ATP synthase to ensure efficient ATP/ADP exchange and energy production. Additionally ANT's interaction with the mPTP implicates it in the apoptotic pathway where it can influence cell survival and death decisions.
Dysfunctional ANT is linked to conditions such as ischemia-reperfusion injury and neurodegenerative diseases. In ischemia-reperfusion injury ANT's role in mPTP formation is important as excessive mPTP opening can lead to cell death. Also mutations in ANT are associated with mitochondrial myopathy and cardiomyopathy where ANT's impaired function affects cardiac and muscle energy metabolism. ANT's relationship with the voltage-dependent anion channel (VDAC) further emphasizes its role in these disease pathways.