Abcam, ab110134, Anti-METTL7B antibody

Size: 50µg
Rabbit Polyclonal METTL7B antibody. Suitable for ELISA, WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TMT1B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ELISA, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMT1B. The exact immunogen used to generate this antibody is proprietary information.Q6UX53

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL7B also known as Methyltransferase-like protein 7B is an enzyme encoded by the METTL7B gene. Mechanically it functions as a putative S-adenosylmethionine-dependent methyltransferase. It has a mass of approximately 23 kDa. This protein is expressed in various tissues with higher expression levels in the lung liver and adipose tissue. The presence of METTL7B in these tissues suggests its roles in multiple physiological processes.
Biological function summary
METTL7B plays a role in lipid metabolism contributing to the biosynthesis and processing of complex lipids. It could be involved in cellular responses to metabolic stresses. METTL7B has not been identified as part of any larger protein complexes but may interact with other proteins involved in lipid metabolic pathways. Its expression levels can influence the metabolic flexibility of cells impacting lipid homeostasis.
Pathways
METTL7B integrates into lipid and energy metabolism. It potentially interacts with the phosphatidylinositol signaling system a pathway important for regulating cellular processes including growth and metabolism. The protein may also relate to key regulatory proteins such as insulin receptor substrates which play roles in metabolic signaling pathways that govern energy homeostasis within cells.
METTL7B has associations with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The dysfunction in its methyltransferase activity could impact lipid accumulation and metabolic regulation contributing to these conditions. Additionally its interaction with metabolic regulators like AMP-activated protein kinase (AMPK) highlights its importance in disease mechanisms where lipid and energy imbalances are involved.