Abcam, ab110264, Anti-COX6A2 antibody [4H2A5]

Size: 250µg
Mouse Monoclonal COX6A2 antibody. Suitable for WB and reacts with Cow samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4H2A5,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Cow,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Purification notes-Near homogeneity as judged by SDS-PAGE. ab110264 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
`COX6A2` also known as cytochrome c oxidase subunit 6A2 is a component of the cytochrome c oxidase complex which is part of the electron transport chain. This protein weighs approximately 9 kDa. It is mainly expressed in muscle tissues both cardiac and skeletal reflecting its significant role in tissues with high energy demands. The `COX6A2` protein contributes to the proper functioning of cytochrome c oxidase aiding in the efficient transfer of electrons from cytochrome c to oxygen the final electron acceptor in the chain.
Biological function summary
`COX6A2` participates in energy production within cells by facilitating mitochondrial oxidative phosphorylation. It is part of the cytochrome c oxidase complex which consists of multiple subunits each playing a unique role in electron transport and proton pumping to generate a proton gradient across the mitochondrial membrane. This proton gradient is essential for ATP synthesis. The activity of `COX6A2` supports normal mitochondrial function and energy homeostasis especially in cells with heavy metabolic requirements.
Pathways
The function of `COX6A2` integrates into the mitochondrial respiratory chain specifically in the oxidative phosphorylation pathway. This pathway is important for ATP generation an important process for cellular energy supplies. Additionally `COX6A2` is associated with the regulation of the apoptosis pathway as disruptions in the respiratory chain can trigger programmed cell death. The function of cytochrome c and subunit interactions underline these pathways with each having pivotal roles in maintaining cellular metabolism and survival.
Disruptions in `COX6A2` activity relate to mitochondrial diseases such as cytochrome c oxidase deficiency which can lead to severe metabolic complications. This deficiency affects energy production in muscles and other tissues by impairing the electron transport chain. Additionally mutations or malfunctions involving `COX6A2` may have links to cardiac disorders due to its strong expression in cardiac muscle. The alteration in `COX6A2` can impact the function of related proteins such as those included in the mitochondrial respiratory chain ultimately affecting energy-dependent tissues and processes.