Abcam, ab110644, Anti-TRADD antibody [EPR3604]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRADD antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3604,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRADD also known as TNFRSF1A-associated via death domain acts mechanically as an adaptor protein that interacts with tumor necrosis factor receptor 1 (TNFR1) and other signaling molecules. It has a mass of approximately 34 kDa. TRADD is expressed in various tissues including the spleen thymus and liver. It contributes to cellular responses by serving as an important component in TNF receptor signaling.
Biological function summary
The adaptor protein TRADD facilitates the transmission of death and survival signals from TNFR1. It forms part of a signaling complex that contributes to the activation of downstream pathways involved in apoptosis and inflammation. By interacting with other adaptor proteins like RIPK1 and FADD TRADD plays a role in assembling signaling complexes that govern cell fate decisions.
Pathways
TRADD is a pivotal player in both the TNF signaling and NF-kB pathways. In the TNF signaling pathway TRADD recruits RIPK1 and FADD leading to downstream activation of caspases and the apoptotic response. In the NF-kB pathway TRADD facilitates the activation of transcription factors that control genes involved in inflammatory responses. These interactions enable TRADD to mediate signals that influence cell survival proliferation and immune responses.
Dysfunction or overexpression of TRADD has connections to various conditions particularly cancer and autoimmune diseases. In cancer aberrant TNF signaling involving TRADD may promote survival and accumulation of malignant cells with overlapping involvement of NF-kB. Autoimmune diseases may arise when altered TRADD function affects inflammatory responses through interactions with TNFR1 and downstream NF-kB mediators. Understanding TRADD's role provides opportunities for therapeutic targeting in these health issues.