Abcam, ab11069, Anti-FSH beta antibody [INN-hFSH-60]

Size: 250µg
Mouse Monoclonal FSH beta antibody. Suitable for ELISA, IHC-P, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human FSHB.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:INN-hFSH-60,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IHC-Fr, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human FSHB.P01225,
Epitope:Directed against the Beta 2 epitope of the Beta subunit of human FSH beta.,
Specificity:Ab11069 Shows strong reactions with hFSH and beta hFSH, but no cross reactivity with hTSH, hLH, hCG, alpha hCG, alpha hFSH. The recognition site is located near the alpha 1 binding site on the hFSH molecule. It is not compatible with other anti hFSH beta antibodies.

Product details:
This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FSH beta subunit known as hFSH or beta FSH is a part of the follicle-stimulating hormone (FSH) which plays a critical role in reproductive processes. The FSH protein consists of two subunits alpha and beta where the beta subunit is responsible for its biological specificity and binding activity. The genes encoding these subunits are mapped on different chromosomes. The FSH beta gene is expressed mainly in the pituitary gland and produces a protein with a molecular mass around 22 kDa. Its expression can vary depending on the physiological needs of the body such as during different phases of the menstrual cycle.
Biological function summary
The hormone FSH stimulates ovarian follicle growth in females and spermatogenesis in males. It acts as part of a larger heterodimeric complex with the alpha subunit. The interactions of these subunits are essential for the function of FSH enabling it to bind to specific cell surface receptors present on target tissues like the gonads. This binding triggers intracellular signaling cascades that facilitate reproductive maturation and function. The intricate behavior of FSH highlights its role in fertility and reproductive health.
Pathways
FSH beta subunit contributes critically to the reproductive hormone signaling and MAPK pathways. It interacts with other reproductive hormones such as luteinizing hormone (LH) to regulate reproductive processes. Upon binding to its receptor FSH activates pathways involving cyclic adenosine monophosphate (cAMP) that mediate ovarian and testicular function. These interactions highlight the role of FSH in coordinating with other proteins to maintain reproductive health and hormonal balance.
FSH plays an important role in conditions like polycystic ovary syndrome (PCOS) and hypogonadism. Altered levels of FSH can lead to abnormal reproductive functions infertility and irregular menstrual cycles. Its interaction with proteins such as inhibin and activin affects its secretion and action. Therapies targeting FSH levels or its signaling pathways can be pivotal in managing these reproductive disorders highlighting its clinical significance.