Abcam, ab110972, Anti-Hepatitis C Virus E1 antibody

Size: 500µL
Goat Polyclonal POLG antibody. Suitable for ELISA, WB, ICC/IF and reacts with Hepatitis C virus samples. Cited in 1 publication.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Hepatitis C virus,
Applications:WB, ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Purification notes-ab110972 is >95% pure by Sodium sulfate precipitation and ion exchange chromatography., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatitis C Virus E1 (HCV E1) also known as glycoprotein E1 is a component of the viral envelope with a mass of approximately 31 kDa. It plays a role in viral entry into host cells by binding to cellular receptors and facilitating fusion with the host membrane. E1 is expressed on the surface of Hepatitis C virions providing structural support. It forms a heterodimer with another envelope protein E2 which is essential for its functionality in the virus life cycle.
Biological function summary
The Hepatitis C Virus E1 protein engages in the process of infecting liver cells. As part of the heterodimeric E1/E2 complex it enables the virus to attach and penetrate host cells which is important for establishing infection. The E1/E2 complex is also important for immune evasion as it can escape neutralizing antibodies due to its high mutation rate. This complex allows Hepatitis C to persist in the host leading to chronic infection.
Pathways
E1 and its partner E2 are integral to the viral replication cycle. The proteins interact with host cell pathways that dictate cell entry and immune response. E1 involves itself in the fusion process and is linked to the endocytosis pathway. Other proteins related through this pathway include CD81 a known receptor for HCV which facilitates the actual uptake of the virus into the host cell.
Hepatitis C Virus E1 plays a significant role in chronic hepatitis C infection and hepatocellular carcinoma. This infection leads to liver inflammation which can progress to fibrosis or even liver cancer. E1 also interacts with proteins like claudin-1 which supports tight junction formation in liver cells and contributes to the spread of the virus enhancing the risk of disease progression. Understanding the function of E1 is important for developing therapies and vaccines against HCV.