Abcam, ab11137, Anti-ProDynorphin antibody

Size: 50µL
Rabbit Polyclonal ProDynorphin antibody. Suitable for IHC-Fr and reacts with Mouse, Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Rat Pdyn.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Pdyn. The exact immunogen used to generate this antibody is proprietary information.P06300,
Specificity:This antibody blocks specifically with leumorphin (rat only). Cells are found in the paraventricular and supraoptic nucleus and fibres in the lateral hypothalamus in rat brain of colchicine treated 4% FA perfused tissue.

Product details:
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 5% Sucrose, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dynorphin B often referred to as Big Dynorphin is an opioid peptide that belongs to the endorphin family. This peptide is derived from the precursor protein prodynorphin also known by the gene symbol PDYN. Dynorphin B typically has a mass of around 3.4 kDa. It expresses mainly in the central nervous system particularly within the hypothalamus hippocampus and spinal cord. These locations correspond to its function as a modulator of neural activity often influencing pain perception and stress response.
Biological function summary
Dynorphin B acts as a neurotransmitter and neuromodulator. It binds to the kappa-opioid receptor forming a complex that modulates synaptic transmission. Dynorphin B influences several neurological processes including the regulation of dopamine levels and the modulation of pain pathways. Given its role in neural signaling dynorphin B is involved in regulating the body's response to stress and addiction mechanisms.
Pathways
The activity of dynorphin B integrates primarily within the nociceptive pathway and stress-related pathways. The peptide's interaction with the kappa-opioid receptor significantly influences these pathways. It's related to other opioid peptides such as beta-endorphin and enkephalins. These interactions affect the release of neurotransmitters and consequent biological responses which are important in the body's adaptation to stress and perception of pain.
Dynorphin B has significant connections to conditions like addiction and depression. In addiction altered levels and signaling of dynorphin B contribute to the reinforcing properties of addictive substances by impacting dopamine transmission. In depression the dysregulation of dynorphin B and its receptor interactions play roles in mood disturbances and stress response. These conditions also relate to the complex interplay with beta-endorphin which suggests overlapping pathways and physiological effects amongst these opioid peptides.