Abcam, ab111694, Anti-TRIM11 antibody

Size: 50µL
Rabbit Polyclonal TRIM11 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM11 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRIM11 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q96F44

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM11 also known as Tripartite Motif Containing 11 is a protein with a mass of approximately 54 kDa. It functions as an E3 ubiquitin ligase facilitating the transfer of ubiquitin from E2 enzymes to target proteins which signals these targets for degradation by the proteasome. This protein is expressed in various tissues with higher levels found in the brain. It plays a role in controlling protein homeostasis and impacts several cellular processes.
Biological function summary
TRIM11 influences neuronal development and survival. It is involved in regulating the degradation of specific substrates important for neuronal functions. TRIM11 is not part of a well-defined complex but it interacts with key proteins that modulate cellular stress responses. This interaction helps in maintaining cellular balance especially under conditions that challenge cellular homeostasis.
Pathways
Several important cellular functions involve TRIM11 notably the ubiquitin-proteasome pathway. TRIM11 interacts with proteins like HIF1α and impacts the hypoxia pathway. By regulating the availability of certain transcription factors TRIM11 can influence how cells respond to low oxygen conditions. Additionally through its ubiquitin ligase activity TRIM11 plays a part in modulating apoptosis highlighting its role in cell survival pathways.
TRIM11 has been associated with neurodegenerative disorders and cancer. In the context of neurodegenerative diseases abnormal regulation of TRIM11 can disrupt normal protein homeostasis in neurons contributing to conditions like Alzheimer's disease. Additionally TRIM11 may impact cancer progression by interacting with and modulating the stability of tumor suppressor proteins such as p53. This link emphasizes its potential as a target for therapeutic advancements in these complex diseases.