Abcam, ab111842, Anti-FUZ antibody

Size: 50µL
Rabbit Polyclonal FUZ antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FUZ aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FUZ aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q9BT04

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111842 is purified by antigen-affinity chromatography., Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FUZ protein also known as fuzzy homolog (Drosophila) functions mechanically as a planar cell polarity protein. Its mass is approximately 51.5 kDa. FUZ expresses in various tissues significantly within the neural tissues. This protein plays an important role in the regulation of cell shape and movement especially in neural crest cells and ependymal motile cilia.
Biological function summary
The FUZ protein participates in complex processes involved in cellular organization and signal transduction. FUZ acts within the cytoskeletal network influencing the cytoskeleton dynamics necessary for cell polarity and orientation. It is not known to be a part of a distinct protein complex but its role connects deeply to the modulation of intracellular signaling pathways necessary for embryonic development and tissue morphogenesis.
Pathways
The FUZ protein engages in neural crest cell pathway and planar cell polarity (PCP) signaling pathway. Within PCP it associates with proteins like Dishevelled (DVL) and Prickle (PRICKLE) to direct cell orientation and polarity. In neural crest formation its regulation impacts proper migration and differentiation indicating its linkage to other cellular proteins such as cadherins and integrins that mediate cell-cell communication and adhesion.
FUZ disruptions correlate with neural tube defects and ciliopathies. Improper expression or mutation in the FUZ gene associates with congenital conditions affecting the neural tube closure. Additionally FUZ contributes to the pathogenesis of ciliopathies where it affects ependymal cilia movement. It connects with proteins like KIF3A and other intraflagellar transport proteins in this context highlighting its relevance to disorders involving ciliary dysfunction.