Abcam, ab111866, Anti-C9orf86 antibody

Size: 50µL
Rabbit Polyclonal C9orf86 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RABL6 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RABL6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q3YEC7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111866 is purified by antigen-affinity chromatography., Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C9orf86 also known as chromosome 9 open reading frame 86 is a protein-coding gene. Although its exact molecular mechanism remains under investigation preliminary data indicate its involvement in transcriptional regulation. C9orf86 possesses a molecular weight of approximately 19 kDa. Expression of C9orf86 occurs in various tissues with heightened levels identified in the cerebral cortex suggesting potential neural functions.
Biological function summary
This protein is implicated in a spectrum of cellular processes including gene expression and possibly signal transduction. Research indicates C9orf86 might participate in regulatory complexes that influence chromatin remodeling. This involvement could affect transcriptional responses to cellular stimuli and contribute to maintaining cellular homeostasis.
Pathways
C9orf86 potentially links to the Wnt signaling pathway impacting cell proliferation and differentiation. It may interact with proteins such as beta-catenin within this pathway to modulate gene transcription. Additionally evidence indicates a partial role in the Notch signaling pathway particularly involving the development and differentiation of neural tissues.
Growing evidence suggests that C9orf86 might associate with neurological disorders like schizophrenia. Variations in C9orf86 expression could influence the pathology of this condition possibly through its interaction with proteins like DISC1. Furthermore altered expression of C9orf86 may also have implications in certain cancers by affecting pathways linked to proliferation and apoptosis.