Abcam, ab112893, Anti-LGB antibody

Size: 1mg
Rabbit Polyclonal LGB antibody. Suitable for WB, ICC/IF, ELISA and reacts with Cow samples. Cited in 10 publications. Immunogen corresponding to Full Length Protein corresponding to Cow LGB.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Cow,
Applications:ICC/IF, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Cow LGB. The exact immunogen used to generate this antibody is proprietary information.P02754

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antiserum was solid phase adsorbed to ensure specificity. ab112893 was isolated by affinity chromatography using antigen coupled to agarose beads., Storage buffer-pH: 6.8 - 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LGB also known as beta-lactoglobulin is a small globular protein with a mass of approximately 18 kDa. It is predominantly expressed in the milk of ruminants including cows sheep and goats. The protein is considered a major whey protein and it forms small soluble aggregates in milk. LGB exhibits the ability to bind hydrophobic molecules which suggests it plays a role in transport or storage of lipophilic molecules within milk.
Biological function summary
This protein functions in the stabilization and transport of fatty acids and other hydrophobic molecules. LGB does not form part of a larger protein complex but can dimerize under certain conditions. It has a notable affinity for binding ligands particularly vitamins and flavor compounds which may significantly influence nutritional and sensory qualities of milk and dairy products.
Pathways
LGB's functional role suggests involvement in metabolic and nutritional pathways related to lipid transport and digestion. It has an indirect relationship with the digestive enzyme lipase as LGB-bound lipids become more accessible for digestion. Furthermore its lipid-binding characteristics support its involvement with fatty acid metabolism playing a role similar to serum albumin in circulating lipid constituents.
LGB is most commonly implicated in food allergies particularly cow's milk allergy. Its antigenic properties make it a significant allergen in humans especially young children. Through this context LGB relates to the immune response proteins such as immunoglobulin E (IgE) which mediate allergic reactions. Understanding these interactions between LGB and immune components remains essential for developing hypoallergenic milk products.