Abcam, ab11388, Anti-Choriogonadotropin subunit beta 3 antibody [INN-hCG-2]

Size: 250µg
Mouse Monoclonal Choriogonadotropin subunit beta antibody. Suitable for ELISA, IHC-P, RIA and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CGB3.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:INN-hCG-2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ELISA, RIASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CGB3.P0DN86

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Choriogonadotropin subunit beta 3 often known as beta hCG or hCG 2 is a vital protein component of the hormone human chorionic gonadotropin (hCG). This protein which has a mass of around 22-25 kDa is necessary for the reproductive process. Primarily expressed in the placental trophoblastic cells chorion and testicular germ cell tumors choriogonadotropin beta subunit plays an instrumental role in pregnancy maintenance and has become a useful marker in clinical diagnostics particularly in prenatal screenings and cancer assays.
Biological function summary
HCG 2 stimulates corpus luteum maintenance during early pregnancy promoting progesterone production which is essential for uterine lining support. The choriogonadotropin beta subunit forms a functional heterodimer with the alpha subunit sharing similarity with other glycoprotein hormone structures like luteinizing hormone (LH). The intact heterodimer acts at the LH/CG receptor revealing its bioactivity in reproductive tissues.
Pathways
The choriogonadotropin beta subunit participates in the reproductive hormone signaling pathways particularly in facilitating reproductive processes. It is closely related to proteins such as luteinizing hormone sharing pathways involved in gonadal steroidogenesis. This connection ensures the regulation of steroid hormones critical for reproduction and sexual development.
Choriogonadotropin beta subunit serves as a marker for conditions like gestational trophoblastic disease and testicular cancer. Abnormal levels of beta hCG indicate pathological states with links to ovarian and testicular tumor markers. Its role alongside other proteins like alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) aids in the diagnosis and monitoring of these malignancies.