Abcam, ab113886, Anti-Synaptogyrin 1 antibody

Size: 50µg
Rabbit Polyclonal Synaptogyrin 1 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SYNGR1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SYNGR1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O43759

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptogyrin 1 also known as SYG1 or Synaptogyrin-1 mechanically functions as an integral membrane protein involved in synaptic vesicle dynamics. It is a protein weighing approximately 29 kDa. Researchers have found SYG1 abundantly expressed within neural tissues particularly the presynaptic terminals of neurons. This protein shows involvement in the regulation of synaptic vesicle availability and neurotransmitter release implying its mechanical importance in synaptic function.
Biological function summary
Synaptogyrin 1 contributes to the modulation of synaptic vesicle cycling and neurotransmitter release. It participates in forming complexes that interact with other synaptic vesicle proteins likely supporting the organization and maintenance of synaptic vesicle pools. The presence of SYG1 in synaptic nerve terminals signifies its role in maintaining synaptic transmission efficiency and neuronal communication over synapses.
Pathways
Synaptogyrin 1 is linked to neurotransmission processes and synaptic vesicle recycling pathways. Researchers recognize its participation in the SNARE complex interplay important for vesicle fusion and neurotransmitter release. SYG1 associates with proteins like Synaptophysin and VAMP2 which all contribute to the maintenance of the synaptic vesicle life cycle ensuring proper communication between neurons.
Synaptogyrin 1 relates to neurological conditions such as schizophrenia and epilepsy. Misexpression or dysfunction of SYG1 disrupts synaptic signal transmission contributing to these disorders. Studies have shown it is associated with proteins such as NRG1 and DISC1 implicated in schizophrenia as well as alterations in glutamatergic pathways linked to epilepsy. Understanding its interaction and regulation could offer insights into therapeutic strategies for synaptic dysfunction-related diseases.