Abcam, ab114113, Anti-ITGA11 antibody

Size: 200µL
Goat Polyclonal ITGA11 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Itga11 aa 1000-1100.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Itga11 aa 1000-1100. The exact immunogen used to generate this antibody is proprietary information.P61622

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab114113 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99.48% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ITGA11 also known as Integrin alpha-11 functions mechanically as an alpha subunit that combines with the beta-1 subunit to form a collagen receptor integrin complex. The protein has a mass of approximately 135 kDa and its expression occurs mainly in fibroblastic cells located within connective tissue including areas like skin and lungs. ITGA11 plays a role in cell adhesion helping mediate interactions between cells and the extracellular matrix which is essential for tissue structure and function.
Biological function summary
ITGA11 influences various cellular processes including cell migration proliferation and differentiation. The protein is part of the alpha-11 beta-1 integrin complex that specifically binds to interstitial collagens. This interaction allows ITGA11 to facilitate communication signals that control cellular behavior. Its effective function in collagen recognition establishes ITGA11 as important for maintaining the structural integrity and repair of tissues particularly during injury or developmental processes.
Pathways
ITGA11 integrates into the collagen-mediated signaling pathway which connects to cellular responses to the extracellular matrix. In particular ITGA11 interacts with other proteins like integrin beta-1 to affect cell survival and movement. Another important pathway involving ITGA11 is the TGF-beta signaling pathway where it contributes to matrix reorganization and fibroblast activation both significant in tissue development and repair mechanisms.
ITGA11 shows association with fibrotic diseases and certain cancers. In fibrosis excessive collagen deposition occurs and ITGA11's interaction with collagen and its regulatory role in fibroblasts can exacerbate this condition. This relationship links ITGA11 to proteins like integrin beta-1 and TGF-beta which are involved in fibrotic tissue transformation. In cancer ITGA11 supports tumor stroma formation contributing to cancer cell survival and spread emphasizing its importance in tumor biology and as a potential therapeutic target.