Abcam, ab114115, Anti-Chromodomain helicase DNA binding protein 9 antibody

Size: 100µg
Rabbit Polyclonal Chromodomain helicase DNA binding protein 9 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CHD9 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CHD9 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q3L8U1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab114115 was affinity purified using an epitope specific to Chromodomain helicase DNA binding protein 9 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Chromodomain helicase DNA binding protein 9 (CHD9) also known as CHD Family Member 9 possesses the function of chromatin remodeling. This protein belongs to the CHD family characterized by the presence of chromodomains that facilitate its role in modifying chromatin structure. CHD9 has a molecular weight of approximately 380 kDa. The expression of CHD9 is varied with higher levels observed in tissues such as the brain liver and heart indicating its broader involvement in cellular processes across different tissues.
Biological function summary
CHD9 plays a role in transcription regulation by altering chromatin configuration to allow access to transcription factors. It associates with other protein complexes to exert its influence on gene expression. Its ability to bind DNA and modify chromatin structure enables the modulation of genes necessary for cellular differentiation and growth processes. The protein's involvement as part of chromatin-remodeling complexes highlights its importance in maintaining the dynamic nature of chromatin structure.
Pathways
CHD9 influences gene expression through interaction with the Wnt and MAPK signaling pathways. It participates in these signaling pathways alongside key players such as β-catenin and ERK proteins which regulate cell proliferation and differentiation. The participation of CHD9 in these pathways highlights its role in cellular signaling and development connecting it to critical cellular functions.
CHD9 shows relevance in certain cancers and neurodevelopmental disorders. Its role in chromatin remodeling ties it to abnormalities in transcription that can contribute to oncogenesis commonly linked with overexpression of other chromatin remodelers. Additionally connections to neurodevelopmental disorders emerge from its expression profile and interaction with proteins such as MeCP2 which are vital in neural development and function.