Abcam, ab114898, Recombinant Human Ephrin A2 protein

Size: 10µg
Recombinant Human Ephrin A2 protein is a Human Full Length protein, in the 1 to 213 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O43921,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ephrin A2 also known as EFNA2 is a member of the ephrin family which plays an important role in cellular processes. This protein is a glycosylphosphatidylinositol (GPI)-anchored ligand for Eph receptors which are a type of receptor tyrosine kinases. Ephrin A2 has a mass of approximately 25 kDa. It is mostly expressed in the nervous system as well as in the endothelial cells of blood vessels. Ephrin A2 is important for mediating cell signaling that affects morphology and cellular movement.
Biological function summary
Ephrin A2 is involved in cell positioning and boundary formation. It is essential during embryonic development for tissue patterning. The ephrin A2 binds to Eph receptors often forming a complex that triggers bidirectional signaling. This complex affects neuronal growth cones guiding axon pathfinding and is significant in neurogenesis. Its signaling impacts cellular adhesion and repulsion which regulates how cells interact with their surroundings and other cells.
Pathways
Ephrin A2 is integrated into the Eph/ephrin signaling pathway which is important for various cellular responses. This signaling impacts the Rho family of GTPases which play a role in mediating cytoskeletal dynamics. Ephrin A2 also interacts with the MAPK/ERK pathway contributing to the regulation of cell proliferation and differentiation. Within these pathways it associates with proteins like EphA4 and ephrin A5 influencing pathway outcomes.
Ephrin A2 has associations with cancer particularly in tumor growth and angiogenesis. Altered Ephrin A2 signaling can contribute to the progression of cancers by affecting vascularization and cell migration. Additionally its dysregulation is linked to neurodegenerative conditions such as Alzheimer's disease. Through these diseases Ephrin A2 interacts with various proteins including amyloid precursor protein and tau which are involved in disease pathologies.